Today : Tuesday - Sep 16, 2014, 08:25am (GMT+5.5)
All News  
Top News
National News
International News
Business News
Sports News
   » Cricket
   » Football
Entertainment News
Sci - Tech
Politics News
Health & Fitness
Education
Travel
Lifestyle
Gulf News
Featured
 
::| Latest News
News in Pictures

Nelson Mandela, who is although seriously sick, is the one making decisions about his own fate, his daughter has said.The comments were made by Zindzi in a joint interview with mother, Winnie Madikizela-Mandela, with British television ITN.They both were critical of public discussions about whether or not the family should keep the ailing Nobel peace laureate alive, news.com.au reports.

Health & Fitness
 

Key regulator protein for kidney disease identified

Monday - Mar 12, 2012, 11:10pm (GMT+5.5)
[+] Text [-]

Washington - A regulator protein has been identified that plays a crucial role in kidney fibrosis, a condition that leads to kidney failure.

The research team led by John Cijiang He, MD, PhD, Professor of Nephrology and Pharmacology and Systems Therapeutics and Avi Ma’ayan, PhD, Assistant Professor of Pharmacology and Systems Therapeutics at Mount Sinai School of Medicine, studied three mouse models of kidney fibrosis.

One group of mice contained HIV viral proteins incorporated into their genome; the second group was injected with a high dose of folic acid; in the third mouse model, kidney filtration was blocked in one kidney. All of these factors cause kidney fibrosis.

The researchers gathered the genetic material of the mice and compared it to the genetic material of mice that did not have kidney fibrosis. Using a new computational systems biology algorithm and software called Expression2Kinases - developed by the Ma’ayan Laboratory at Mount Sinai - the results from these experiments were analyzed.

They found that HIPK2, a protein kinase, or regulator, was highly active in the mice with kidney fibrosis. HIPK2 regulates the way certain genes are expressed and when HIPK2 is highly active this leads to kidney fibrosis. Drs He and Ma’ayan also found that when they eliminated HIPK2, fibrosis was less prominent and the condition of the mice significantly improved.

“Our findings have important implications for people with kidney diseases, patients I treat every day,” said Dr He.

“Protein kinases like HIPK2 are highly effective therapeutic targets. We look forward to exploring this further,” he added.

Now, Mount Sinai scientists can work to develop a drug intervention that inhibits the activity of HIPK2.

“This study is an important example of the translational research we are doing at Mount Sinai.

“Using algorithms and software developed here, we worked with Dr He, who is a kidney disease physician and scientist, to better understand what causes kidney fibrosis, and we are now one step closer to finding a therapeutic solution to a complex disease that affects millions of Americans,” said Dr Ma’ayan.

The research is published in the March 11 issue of Nature Medicine.





|

Rating (Votes: )   

blog comments powered by Disqus

Other Articles:
Ten best foods to reduce cholesterol (12th Mar, 2012)
Nutrition-tips for pregnant working women (12th Mar, 2012)
Ten Tips for a healthy heart (12th Mar, 2012)
Southampton varsity project could herald cheaper and more efficient biotechnology (12th Mar, 2012)
Protein found in blood could help prevent cardiovascular disease (12th Mar, 2012)
Common bacterial STD more than doubles HIV risk in women (12th Mar, 2012)
Talk therapy better than sleeping pills for treating insomnia (12th Mar, 2012)
Workout review: Kickboxing for fitness (10th Mar, 2012)
Black tea health benefits (10th Mar, 2012)
Honey is rich in health (10th Mar, 2012)
Using your ‘wrong’ hand to stir your tea helps you control your anger (10th Mar, 2012)
Many women trying to conceive worry about their partner’s sperm count (10th Mar, 2012)
Arthritis invites higher risk of heart attacks (9th Mar, 2012)
LSD lowers relapse among alcoholics (9th Mar, 2012)
Cancer drug successfully purges hidden HIV virus (9th Mar, 2012)
New aspirin curbs 11 kinds of cancer, shrinks tumours (9th Mar, 2012)
Alcohol consumption ‘may help lower stroke risk in women’ (9th Mar, 2012)
Women have ‘lower risk of dying from heart failure’ than men (9th Mar, 2012)
Growing old or overweight ‘does not significantly impact happiness’ (9th Mar, 2012)
Moderate wine consumption ‘may have good effect on lung function’ (9th Mar, 2012)
Maternal obesity may affect brain development of premature infants (9th Mar, 2012)
Aging, obesity no bar to happiness (9th Mar, 2012)
Baby Falak to be discharged in a week (9th Mar, 2012)
Genetic changes make cancer deadly (9th Mar, 2012)
French maritime pine bark extract may help ease menopause symptoms (9th Mar, 2012)




Contact Us | Advertise with Us | Privacy Policy | Disclaimer | Terms of Use