Peaches, plums, nectarines offer new hope against obesity, diabetes

Washington -  Stone fruits – peaches, plums and nectarines – have bioactive compounds that can potentially fight-off obesity-related diabetes and cardiovascular disease, according to new  studies by Texas AgriLife Research.

According to Dr. Luis Cisneros-Zevallos, AgriLife Research food scientist, the study showed that these compounds could be a weapon against “metabolic syndrome,” in which obesity and  inflammation lead to serious health issues.

“In recent years obesity has become a major concern in society due to the health problems associated to it,” said Cisneros-Zevallos, who also is an associate professor at Texas A and M  University.

“In the U.S., statistics show that around 30 percent of the population is overweight or obese, and these cases are increasing every year in alarming numbers,” the researcher noted.

While he acknowledged that lifestyle, genetic predisposition and diet play a major role in one’s tendency toward obesity, “the major concern about obesity is the associated disease known as  metabolic syndrome.

“Our studies have shown that stone fruits – peaches, plums and nectarines – have bioactive compounds that can potentially fight the syndrome,” Cisneros-Zevallos said.

“Our work indicates that phenolic compounds present in these fruits have anti-obesity, anti-inflammatory and anti-diabetic properties in different cell lines and may also reduce the oxidation

of bad cholesterol LDL which is associated to cardiovascular disease,” he stated.

What is unique to these fruits, he said, is that their mixture of the bioactive compounds work simultaneously within the different components of the disease.

“Our work shows that the four major phenolic groups – anthocyanins, clorogenic acids, quercetin derivatives and catechins – work on different cells – fat cells, macrophages and vascular

endothelial cells,” he explained.

“They modulate different expressions of genes and proteins depending on the type of compound.

“However, at the same time, all of them are working simultaneously in different fronts against the components of the disease, including obesity, inflammation, diabetes and cardiovascular

disease,” he explained.

Cisneros-Zevallos said this is believed to be the first time that “bioactive compounds of a fruit have been shown to potentially work in different fronts against a disease.”

“Each of these stone fruits contain similar phenolic groups but in differing proportions so all of them are a good source of health promoting compounds and may complement each other,” he

said, adding that his team plans to continue studying the role of each type of compound on the molecular mechanisms and confirm the work with mice studies.

The finding will be presented at the American Chemical Society in Philadelphia next August.