Scientists pinpoint brain receptor linked with rage

Washington -  Scientists have identified a brain receptor, an enzyme monoamine oxidase A, whose malfunctioning can trigger sudden violence, explosive outbursts and hostile  overraction to stress in mice.

By blocking the receptor, which also exists in humans, scientists stripped the mice of their extreme aggressiveness, potentially paving the way to new treatment for severely aggressive  behaviour.

The findings by researchers from the University of Southern California (USC) and Italy are a significant breakthrough in developing drug targets for pathological aggression, a component in  many common psychological disorders, including Alzheimer's disease, autism, bipolar disorder and schizophrenia, the Journal of Neuroscience reports.

"From a clinical and social point of view, reactive aggression is absolutely a major problem," said Marco Bortolato, research assistant professor of pharmacology and pharmaceutical  sciences at the USC School of Pharmacy, who led the study. "We want to find the tools that might reduce impulsive violence," said Bortolato, according to an USC statement.

A large body of independent research, including past work by Bortolato and his colleague and senior study author Jean Shih, has identified low levels of the enzyme monoamine oxidase A  (MAO A). Both male humans and mice with congenital deficiency of the enzyme respond violently in response to stress.