Brain’s ‘reward’ chemical receptors may protect against alcohol-induced damage

Washington -  Receptors for dopamine, the brain’s ‘reward’ chemical, may play a protective role against alcohol-induced brain damage, a new study has suggested.

Brain scans of two strains of mice imbibing significant quantities of alcohol reveal serious shrinkage in some brain regions - but only in mice lacking a particular type of receptor for  dopamine.

“This study clearly demonstrates the interplay of genetic and environmental factors in determining the damaging effects of alcohol on the brain, and builds upon our previous findings suggesting a protective role of dopamine D2 receptors against alcohol’s addictive effects,” said study author Foteini Delis, a neuroanatomist with the Behavioral Neuropharmacology and  Neuroimaging Lab at Brookhaven.

“These studies should help us better understand the role of genetic variability in alcoholism and alcohol-induced brain damage in people, and point the way to more effective prevention and  treatment strategies,” coauthor and Brookhaven/NIAA neuroscientist Peter Thanos stated.

The current study specifically explored how alcohol consumption affects brain volume - overall and region-by-region - in normal mice and a strain of mice that lack the gene for dopamine D2  receptors.

Half of each group drank plain water while the other half drank a 20 percent ethanol solution for six months. Then scientists performed magnetic resonance imaging (MRI) scans on all the

mice and compared the scans of those drinking alcohol with those from the water drinkers in each group.

The scans showed that chronic alcohol drinking induced significant overall brain atrophy and specific shrinkage of the cerebral cortex and thalamus in the mice that lacked dopamine D2  receptors, but not in mice with normal receptor levels. Mice in both groups drank the same amount of alcohol.

“This pattern of brain damage mimics a unique aspect of brain pathology observed in human alcoholics, so this research extends the validity of using these mice as a model for studying  human alcoholism,” Thanos said.

In humans, these brain regions are critically important for processing speech, sensory information, and motor signals, and for forming long-term memories. So this research helps explain why  alcohol damage can be so widespread and detrimental.

“The fact that only mice that lacked dopamine D2 receptors experienced brain damage in this study suggests that DRD2 may be protective against brain atrophy from chronic alcohol  exposure,” Thanos said.

“Conversely, the findings imply that lower-than-normal levels of DRD2 may make individuals more vulnerable to the damaging effects of alcohol.”

“The increased addictive liability and the potentially devastating increased susceptibility to alcohol toxicity resulting from low DRD2 levels make it clear that the dopamine system is an  important target for further research in the search for better understanding and treatment of alcoholism,” Thanos added.

The study has been published in Alcoholism: Clinical and Experimental Research.