Today : Tuesday - Sep 02, 2014, 02:29am (GMT+5.5)
All News  
Top News
National News
International News
Business News
Sports News
   » Cricket
   » Football
Entertainment News
Sci - Tech
Politics News
Health & Fitness
Education
Travel
Lifestyle
Gulf News
Featured
 
::| Latest News
News in Pictures

Reliance Communications has made full repayment of two loans amounting to $1 billion (around Rs 6,000 crore), during the quarter ended June 30.The repayments have been from the company's rupee resources.

Sci - Tech
 

Alzheimer’s spreads through linked nerve cells

Friday - Mar 23, 2012, 01:10am (GMT+5.5)
[+] Text [-]

Washington - Alzheimer’s disease and other forms of dementia may spread within nerve networks in the brain by moving directly between connected neurons, instead of in  other ways proposed by scientists, such as by propagating in all directions, results of a new study suggested.

The researchers behind the study were led by neurologist and MacArthur Foundation “genius award” recipient William Seeley, MD, from the UCSF Memory and Aging Center, and  post-doctoral fellow Helen Juan Zhou, PhD, now a faculty member at Duke-NUS Graduate Medical School in Singapore.

They concluded that a nerve region’s connectedness to a disease hot spot trumps overall connectedness, spatial proximity and loss of growth-factor support in predicting its vulnerability to  the spread of disease in some of the most common forms of dementia, including Alzheimer’s disease.

The finding, based on new magnetic resonance imaging research (MRI), raises hopes that physicians may be able to use MRI to predict the course of dementias – depending on where within  an affected network degenerative damage is first discovered – and that researchers may use these predicted outcomes to determine whether a new treatment is working.

Network modeling combined with functional MRI might serve as an intermediate biomarker to gauge drug efficacy in clinical trials before behavioral changes become measurable, according

to Seeley.

“Our next goal is to further develop methods to predict disease progression, using these models to create a template for how disease will progress in the brain of an affected individual,”

Seeley said.

“Already this work suggests that if we know the wiring diagram in a healthy brain, we can predict where the disease is going to go next. Once we can predict how the network will change

over time we can predict how the patient’s behaviour will change over time and we can monitor whether a potential therapy is working,” he stated.

The new evidence suggests that different kinds of dementias spread from neuron to neuron in similar ways, even though they act on different brain networks, according to Seeley.

Seeley’s previous work and earlier clinical and anatomical studies showed that the patterns of damage in the dementias are linked to particular networks of nerve cells, but until now

scientists have found it difficult to evaluate in humans their ideas about how this neurodegeneration occurs.

In the current study, the researchers modeled not only the normal nerve network that can be affected by Alzheimer’s disease, but also those networks affected by frontotemporal dementia

(FTD) and related disorders, a class of degenerative brain diseases identified by their devastating impact on social behaviours or language skills.

The scientists mapped brain connectedness in 12 healthy people. Then they used data from patients with the five different diseases to map and compare specific regions within the networks

that are damaged by the different dementias.

“For each dementia, we looked at four ideas that scientists often bring up to explain how dementia might target brain networks. The different proposed mechanisms lead to different

predictions about how a region’s place in the healthy network affects its vulnerability to disease,” Seeley explained

Details of the finding have been reported in the March 22 edition of the journal Neuron.





|

Rating (Votes: )   

blog comments powered by Disqus


Related Articles:
» Google breaks 2005 promise not to show banner ads on web search results
» Samsung Galaxy S4 unit sales exceeded 40 million in past six months
» Microsoft beats expectations with 17-percent profit surge in Q3
» Twitter seeks $10.9bn valuation in IPO
» BlackBerry introduces new smartphone priced at Rs.39,990
» Apple announces latest OS Mavericks for free download
» Apple unveils latest iPad Air, Macs and new OS
» India's Mars mission Nov 5
» Google accused of making `library visits` history!
» Google Doodle celebrates 216th anniversary of world’s first parachute jump
» Nokia Lumia 1320 likely to be unveiled today
» Kudankulam n-power plant generates 160 MW
» Power generation at Kudankulam n-plant begins
» Twitter considering killing no-longer profitable #Music mobile app
» Latest iPad5 to be thinner, lighter, sans TouchID
» Airtel acquires Qualcomm’s 4G company
» Google shares soar `all-time high` in Q3
» Microsoft updates Windows 8 with start button, Facebook app and better multitasking
» Kobo introduces e-reader tablets in India
» eBay forecasts lower-than-expected Q4 profit and sales
» HCL Technologies' Q1 profit rises 64 percent, tops estimate
» Online database of disease genes that could be targeted with drugs
» Iran to launch second monkey into space next month
» New genetic pathways involved in bladder cancer identified
» Explosive dynamic behaviour on Twitter similar to horde behaviour in financial market


Other Articles:
Bright spots on giant asteroid `puzzling` (23rd Mar, 2012)
Web economy to hit 4.2 trillion dollars as users opt Internet over sex (23rd Mar, 2012)
Trees may help generate electricity in air (23rd Mar, 2012)
Powerful cheek cells offer promise for combating immune system diseases (23rd Mar, 2012)
Southampton varsity research could significantly reduce the need for clinical animal testing (22nd Mar, 2012)
Holding a gun makes you assume others are carrying too (22nd Mar, 2012)
Autism risk gene may be behind differences in brain structure (22nd Mar, 2012)
Mercury’s core `larger and more complex than expected` (22nd Mar, 2012)
Potential for wind energy in India nearly 30 times higher than thought (22nd Mar, 2012)
Brain function differs in kids with math anxiety (22nd Mar, 2012)
People without sense of smell have higher social insecurity (22nd Mar, 2012)
Astronomers get widest deep view of sky ever recorded (22nd Mar, 2012)
Soon, blood test may predict heart attack risk (22nd Mar, 2012)
Baboons and infants exhibit similar gesturing behaviour (22nd Mar, 2012)
Dutch engineer `flies` using android-powered bird wings in viral video (22nd Mar, 2012)
Watching `Harry Potter` could make kids more creative (22nd Mar, 2012)
Structure of `salvia` receptor identified (22nd Mar, 2012)
Male fruit flies put more effort into mating after meeting rivals (21st Mar, 2012)
Smell of food could determine bite sizes (21st Mar, 2012)
Nokia’s ‘magnetic tattoos’ could alert you when your phone rings (21st Mar, 2012)
‘Cosmic crumbs’ may tell tale of explosive stars with good table manners (21st Mar, 2012)
NASA satellite probes origin of exploding stars (21st Mar, 2012)
Personality traits traced in brain (21st Mar, 2012)
Not just birds, human noise affects plants too (21st Mar, 2012)
Soon, camera that uses opaque walls as ‘mirrors’ to peer around corners (21st Mar, 2012)




Contact Us | Advertise with Us | Privacy Policy | Disclaimer | Terms of Use