Today : Tuesday - Sep 23, 2014, 05:50am (GMT+5.5)
All News  
Top News
National News
International News
Business News
Sports News
   » Cricket
   » Football
Entertainment News
Sci - Tech
Politics News
Health & Fitness
Gulf News
::| Latest News
News in Pictures

Reliance Communications has made full repayment of two loans amounting to $1 billion (around Rs 6,000 crore), during the quarter ended June 30.The repayments have been from the company's rupee resources.

Sci - Tech

Potential target to lower risk of high blood pressure identified

Wednesday - Apr 04, 2012, 11:20pm (GMT+5.5)
[+] Text [-]

Washington - University of Southampton scientists have discovered a new process that controls the ability of arteries to regulate blood pressure.

The finding could lead to a better understanding of the causes of cardiovascular disease and the development of new treatments.
Arteries are able to control blood pressure by relaxing and constricting. In healthy people, the ability of arteries to relax or constrict is kept in balance. However, this balance shifts in people  who are at risk of developing high blood pressure or atherosclerosis.

There is more constriction within the arteries so blood cannot flow freely increasing the risk of heart attacks and stroke.

Southampton researchers led by Dr Graham Burdge, Reader in Human Nutrition, showed that polyunsaturated fats, which are converted into fat-like molecules called eicosanoids in order to  make arteries constrict, are made by the muscle cells in the arteries rather than being taken up from blood, as previously thought.

By blocking the action of two enzymes that create polyunsaturated fats, the researchers were able to reduce the constriction of arteries allowing blood to flow more freely, therefore lowering  the risk of high blood pressure.

The research also found that this process changed in arteries that showed the early signs of causing high blood pressure. They found changes in the epigenetic ‘switches’ that control one  of the key genes for making polyunsaturated fats, while another gene over-compensated for this change.

“This is an important finding. Cardiovascular disease is an increasing public health issue. In 2009, over 180,000 people died from cardiovascular disease in the UK – that is one in three of all  deaths,” Dr Burdge noted.

“Discovering a new process which controls how arteries work, and finding that it can be modified in the laboratory, raises a strong possibility for developing new medicines that may lead to  better ways of treating cardiovascular disease.

“Currently, it is difficult for doctors to screen people at risk of cardiovascular disease before symptoms develop. However, a test based on the epigenetic changes we have found could  provide a new way of screening people for risk of cardiovascular disease, and, in time, it might also be possible to correct this epigenetic defect,” Dr Burdge added.

The study funded by the British Heart Foundation has been published in PLoS ONE.


Rating (Votes: )   

blog comments powered by Disqus

Related Articles:
» Google breaks 2005 promise not to show banner ads on web search results
» Samsung Galaxy S4 unit sales exceeded 40 million in past six months
» Microsoft beats expectations with 17-percent profit surge in Q3
» Twitter seeks $10.9bn valuation in IPO
» BlackBerry introduces new smartphone priced at Rs.39,990
» Apple announces latest OS Mavericks for free download
» Apple unveils latest iPad Air, Macs and new OS
» India's Mars mission Nov 5
» Google accused of making `library visits` history!
» Google Doodle celebrates 216th anniversary of world’s first parachute jump
» Nokia Lumia 1320 likely to be unveiled today
» Kudankulam n-power plant generates 160 MW
» Power generation at Kudankulam n-plant begins
» Twitter considering killing no-longer profitable #Music mobile app
» Latest iPad5 to be thinner, lighter, sans TouchID
» Airtel acquires Qualcomm’s 4G company
» Google shares soar `all-time high` in Q3
» Microsoft updates Windows 8 with start button, Facebook app and better multitasking
» Kobo introduces e-reader tablets in India
» eBay forecasts lower-than-expected Q4 profit and sales
» HCL Technologies' Q1 profit rises 64 percent, tops estimate
» Online database of disease genes that could be targeted with drugs
» Iran to launch second monkey into space next month
» New genetic pathways involved in bladder cancer identified
» Explosive dynamic behaviour on Twitter similar to horde behaviour in financial market

Other Articles:
Bilingual kids better at multitasking than single language speakers (4th Apr, 2012)
Google to create virtual tour of world’s top galleries (4th Apr, 2012)
Europe's biggest dinosaur skull found in Spain (4th Apr, 2012)
Brain stimulation may help improve speech, memory and numerical abilities (4th Apr, 2012)
Hypnosis provides lasting relief from bowel disorder symptoms (4th Apr, 2012)
Systemic inflammation may cause depression (4th Apr, 2012)
Controversial bird flu studies cleared for publication (4th Apr, 2012)
World’s first flying car takes its first test flight in NY (3rd Apr, 2012)
Sounds of Mars and Venus revealed for first time (3rd Apr, 2012)
Sparrows `sing out loud` to be heard in noisy cities (3rd Apr, 2012)
Humans used fire 1 million years ago (3rd Apr, 2012)
Oxford University set to launch driverless cars (2nd Apr, 2012)
Smell of baked potato can make us feel happier (2nd Apr, 2012)
`Intimate relationship` between metastatic breast cancer and arthritis identified (2nd Apr, 2012)
Facebook use may up risk of eating disorders, low self-esteem (2nd Apr, 2012)
DNA sequencing may help identify `driver` mutations in cancer (2nd Apr, 2012)
Bendable e-readers come closer to reality (2nd Apr, 2012)
`World’s creepiest` women stalking app pulled after `tool for rapists` outcry (2nd Apr, 2012)
Hubble captures dusty lanes in `UFO` Galaxy (2nd Apr, 2012)
China lays claim to `biggest’ catalogue of galaxy clusters (2nd Apr, 2012)
Black holes `eat binary star partners` to grow (2nd Apr, 2012)
Scientists say earth makeup differs from sun (2nd Apr, 2012)
Bees 'self-medicate' when infected (2nd Apr, 2012)
New, mobile app pulls data from Facebook and Foursquare to `stalk` women (2nd Apr, 2012)
Pinterest-like site Snatchly lets users ‘pin’ porn on virtual boards (2nd Apr, 2012)

Contact Us | Advertise with Us | Privacy Policy | Disclaimer | Terms of Use