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Sci - Tech

How stress affects humans

Tuesday - Apr 10, 2012, 02:42pm (GMT+5.5)
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How stress affects humansWashington - By studying social stress that moulds monkey immune system, researchers have shed light on how the stress of low socioeconomic status may impact human health and how individuals’ bodies adapt after a shift in their social environment.

Researchers, who conducted the study with rhesus macaques at the Yerkes National Primate Research Center, insisted that if a monkey’s social status changes, her immune system changes along with it.

Researchers led by Jenny Tung, PhD, said they can predict a rhesus macaque’s rank within a small group by examining gene expression levels in her immune cells.

Primate researchers can tell macaques’ social rank by watching them engage in competitive interactions, such as grooming and accessing food and water.

Tung and her colleagues studied 10 groups of female macaques (five each) in which researchers could manipulate individuals’ social rank. Before being placed into new groups, all of the macaques started out as middle rank.

“In the wild, macaques inherit their social rank from their mothers” Tung said.

“But in our research, the order of introduction determines rank; the newcomer is generally lower status. When some macaques’ status changed after a newcomer arrived, so did their patterns of immune system gene activity.”

The researchers used microarrays, a technology that allows them to scan thousands of genes and read the expression levels, to look at the macaques’ immune cells. The gene activity that changed the most depending on social rank was what controlled inflammation.

Previous studies have found lower status macaques have higher levels of inflammation and have changes in their levels of hormones that indicate they’re under more stress.

Based on the pattern of gene activity, the researchers could, without looking at a monkey’s identity, predict whether that animal was high (rank 1 or 2), middle or low (rank 4 or 5) with 80 percent accuracy.

Seven monkeys’ social ranks changed because other individuals were moved. When this happened, the researchers were able to take blood samples before and after the shift.

The gene scans revealed the pattern of immune system activity changed along with these monkeys’ social ranks. Here, social rank post-shift could be predicted to 86 percent accuracy (six out of seven).

“There’s a concerning side to this kind of research, in that an individual’s social environment probably partially determines health status,” Tung said.

“But there’s also a hopeful side. For the seven females that changed ranks, their gene status changed with them.” Dr. Mark Wilson, PhD, chief of the Division of Developmental and Cognitive Neuroscience at Yerkes and director of the center's Biomarkers Core Laboratory, said.

“That they are not stuck in place says something more broadly about the capacity for change within human society. With these studies, we are showing we do have the ability to advance from our roots and live more healthful lives,” Dr. Wilson added.

The study has been published in the Proceedings of the National Academy of Sciences Early Edition.


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