Today : Friday - Aug 01, 2014, 09:23pm (GMT+5.5)
All News  
Top News
National News
International News
Business News
Sports News
   » Cricket
   » Football
Entertainment News
Sci - Tech
Politics News
Health & Fitness
Education
Travel
Lifestyle
Gulf News
Featured
 
::| Latest News
News in Pictures

Reliance Communications has made full repayment of two loans amounting to $1 billion (around Rs 6,000 crore), during the quarter ended June 30.The repayments have been from the company's rupee resources.

Sci - Tech
 

Key target molecule for Alzheimer's therapy identified

Sunday - Aug 01, 2010, 02:47pm (GMT+5.5)
[+] Text [-]

Washington (ANI) - Alzheimer patients have high accumulations of the beta-amyloid - appearing in the form of plaques - in their brain. The precursors of these plaques are thought to be the underlying cause of the nerve cell loss that leads to Alzheimer's. Now scientists have identified an enzyme, alpha secretase, which cleaves the amyloid precursor protein (APP) without forming beta-amyloid.

The work, by researchers at the German Centre for Neurodegenerative Diseases (DZNE) and Ludwig Maximilian University of Munich (LMU), appears in EMBO Journal.

The research team has now been able to show that the enzyme ADAM10 alone is responsible for the specific cleavage. Dr. Stefan Lichtenthaler and his team developed highly specific antibodies that can identify the different cleavage products of the precursor protein in the brain cells of mice and in human cell cultures.

Using a special technique called RNA interference, the researchers managed to block each of the three genes that code for the three ADAM enzymes under suspicion. An analysis of the cleavage products revealed that the ADAM10 gene was the only one able to prevent the formation of beta-amyloids. They confirmed their results using mass spectrometry.

"In ADAM10 we have identified a target molecule that plays a central role in the development of the molecular processes in Alzheimer's disease. We know that ADAM10 is less active in Alzheimer patients," said Dr. Lichtenthaler. When ADAM10 is less active, the precursor protein is more likely to be cleaved in a way that promotes the formation of beta-amyloids.

"It is possible that less ADAM10 activity could increase susceptibility to Alzheimer's disease. If that is the case, stimulating ADAM10 could be an important mechanism for therapy. But our antibodies also open up new possibilities for diagnosing and preventing the disease," said Lichtenthaler.

The antibodies could be used to measure ADAM10 activity in spinal fluid and, by extension, identify persons who may have an increased risk of developing Alzheimer's disease. A series of experiments to examine this possibility is already underway.





|

Rating (Votes: )   

blog comments powered by Disqus

Other Articles:
Monkeys go bananas at the sight of flying squirrels (1st Aug, 2010)
New theory to reveal why midcontinent faults generate earthquakes? (1st Aug, 2010)
Drink red wine for healthier life (1st Aug, 2010)
Boffins develop faster, reliable new technique to detect secret graves (1st Aug, 2010)
Oral contraceptives, HRT may protect women against brain disorder (1st Aug, 2010)
Scientists unveil new method to heat water in 'nano bathtubs' (1st Aug, 2010)
Scientists report declining biodiversity in Chernobyl exclusion zone (1st Aug, 2010)
Novel procedure uses stem cells in windpipe transplant for cancer patients (1st Aug, 2010)
Is 'social engineering' better than software skills to hack into computers? (1st Aug, 2010)
Drug-resistant strain of E. coli emerges in US (1st Aug, 2010)
Boffins unravel secret of ancient Mayan dye's longevity (31st Jul, 2010)
New theory to reveal why midcontinent faults generate earthquakes? (31st Jul, 2010)
Monkeys go bananas at the sight of flying squirrels (31st Jul, 2010)
Key target molecule for Alzheimer's therapy identified (31st Jul, 2010)
Star Wars-themed #Wookieleaks parodies circulate on Twitter (31st Jul, 2010)
Orissa launches online service to address grievances (31st Jul, 2010)
Reading terrorists' minds about imminent attacks may soon be possible (31st Jul, 2010)
Genetic changes linked to diet, alcohol could predict breast cancer severity (31st Jul, 2010)
US troops to get translation devices to break language barrier on foreign shores (31st Jul, 2010)
Sex is good for your brain (31st Jul, 2010)
Texting may increase medication compliance in teen diabetics (31st Jul, 2010)
Babies raised by working mums don't necessarily suffer cognitive setbacks (31st Jul, 2010)
'Crippled' NASA Spirit Mars Rover may never call home ever again (31st Jul, 2010)
Sea squirt study offers insight into early development of human embryos (31st Jul, 2010)
Trojan asteroids around Neptune could turn into comets that might hit Earth (31st Jul, 2010)




Contact Us | Advertise with Us | Privacy Policy | Disclaimer | Terms of Use