“A cure for cancer: Cracking the holy grail of medical science”

Emperor Constantine V humiliates nineteen high-ranking officials, after discovering a plot against him. He executes the leaders, Constantine Podopagouros and his brother Strategios.

The Dutch city of Ommen receives city rights and fortification rights from Otto III, the Archbishop of Utrecht.

Regent George Mouzalon and his brothers are killed during a coup headed by the aristocratic faction under Michael VIII Palaiologos, paving the way for its leader to ultimately usurp the throne of the Empire of Nicaea.

Philip III, although suffering from dysentery, becomes King of France following the death of his father Louis IX, during the Eighth Crusade. His uncle, Charles I of Naples, is forced to begin peace negotiations with Muhammad I al-Mustansir, Hafsid Sultan of Tunis.<span class="mw-reflink-text" id="mw...

The Honourable Artillery Company, the oldest surviving regiment in the British Army, and the second most senior, is formed.

António Mota and a few companions become the first Europeans to visit Japan.