12:03 am - Thursday August 22, 2019

How brain distinguishes one scent from another

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Washington –  Researchers have used the fruit fly to find out how the brain integrates multiple signals to identify one unique smell.

A team led by Associate Professor Glenn Turner has described how a group of neurons in the fruit fly brain recognize multiple individual chemicals in combination in order to define, or remember, a single scent.

The olfactory system of a fruit fly begins at the equivalent of our nose, where a series of neurons sense and respond to very specific chemicals.

These neurons pass their signal on to a group of cells called projection neurons. Then the signal undergoes a transformation as it is passed to a body of neurons in the fly brain called Kenyon cells.

Kenyon cells have multiple, extremely long protrusions that grasp the projection neurons with a claw-like structure. Each Kenyon cell claw is wrapped tightly around only one projection neuron, meaning that it receives a signal from just one type of input.

In addition to their unique structure, Kenyon cells are also remarkable for their selectivity. Because they’re selective, they aren’t often activated. Yet little is known about what in fact makes them decide to fire a signal.

Turner and colleague Eyal Gruntman, who is lead author on their new paper, used cutting-edge microscopy to explore the chemical response profile for multiple claws on one Kenyon cell.

They found that each claw, even on a single Kenyon cell, responded to different chemicals. Additional experiments using light to stimulate individual neurons (a technique called optogenetics) revealed that single Kenyon cells were only activated when several of their claws were simultaneously stimulated, explaining why they so rarely fire.

Taken together, this work explains how individual Kenyon cells can integrate multiple signals in the brain to “remember” the particular chemical mixture as a single, distinct odor .

The study findings have been published in journal Nature Neuroscience.

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